Uridine | 58-96-8

Uridine ni nucleoside ya pyrimidine ikora nk'ibanze byubaka RNA (aside ribonucleic), bumwe mu bwoko bubiri bwa acide nucleique bukenewe mu kubika no guhererekanya amakuru akomoka mu ngirabuzimafatizo.

Imiterere ya shimi: Uridine igizwe na pyrimidine base uracil ifatanye na karubone eshanu ya karubone ikoresheje β-N1-glycosidic.

Uruhare rw'ibinyabuzima:

Inzira yo kubaka RNA: Uridine nigice cyingenzi cya RNA, aho ikora umugongo wa molekile ya RNA hamwe nizindi nucleoside nka adenosine, guanosine, na cytidine.

Intumwa RNA (mRNA): Muri mRNA, ibisigisigi bya uridine bikubiyemo amakuru akomokamo mugihe cyo kwandukura, bitwaje amabwiriza ava muri ADN kugeza kumashini ya proteyine synthesis.

Kwimura RNA (tRNA): Uridine nayo ihari molekile ya intRNA, aho igira uruhare muguhindura ibisobanuro ikamenya code yihariye kandi igatanga aside amine ijyanye na ribosome.

Metabolism: Uridine irashobora guhindurwa de novo muri selile cyangwa ikaboneka mumirire. Ikorwa binyuze mu guhinduranya imisemburo ya orotidine monophosphate (OMP) cyangwa monofosifate ya uridine (UMP) mu nzira ya pyrimidine biosynthesis.

Akamaro ka Physiologique:

Neurotransmitter Precursor: Uridine igira uruhare mumikorere yubwonko niterambere. Nibibanziriza synthesis ya fosifolipide yubwonko, harimo na fosifatiqueylcholine, ningirakamaro muburyo bwa neuronal membrane hamwe na signal ya neurotransmitter.

Ingaruka za Neuroprotective: Uridine yakozweho ubushakashatsi kubishobora kuba biterwa na neuroprotective hamwe nubushobozi bwayo bwo kongera imikorere ya synaptic na plastike ya neuronal.

Ubushobozi bwo kuvura:

Uridine n'ibiyikomokaho byakorewe iperereza ku buryo bushobora gukoreshwa mu kuvura indwara zifata ubwonko, harimo n'indwara ya Alzheimer n'indwara.

Kwiyongera kwa Uridine byashakishijwe nkingamba zo gushyigikira imikorere yubwenge no kugabanya ibimenyetso bifitanye isano nindwara zifata ubwonko.

Inkomoko y'ibiryo: Uridine iboneka bisanzwe mubiribwa bitandukanye, harimo inyama, amafi, imboga, n'ibikomoka ku mata.