Tacrolimus | 104987-11-3

Tacrolimus, izwi kandi ku izina ryayo ry'ubucuruzi Prograf mu bandi, ni imiti ikomeye ikingira indwara ikoreshwa cyane cyane mu guhinduranya ingingo mu rwego rwo kwirinda kwangwa.

Uburyo bwibikorwa: Tacrolimus ikora ihagarika calcineurine, fosifata ya protein igira uruhare runini mugukora T-lymphocytes, ari selile selile zigira uruhare mukwanga ibihingwa. Mu guhagarika calcineurine, tacrolimus ihagarika umusaruro wa cytokine itera umuriro kandi ikabuza gukora T-selile, bityo igahagarika ubudahangarwa bw'umubiri urwanya urugingo rwatewe.

Ibyerekana: Tacrolimus yerekanwa kuri prophylaxis yo kwangwa ingingo ku barwayi bahabwa umwijima wa allogeneic, impyiko, cyangwa umutima. Bikunze gukoreshwa hamwe nubundi buryo bwo gukingira indwara nka corticosteroide na mycophenolate mofetil.

Ubuyobozi: Tacrolimus isanzwe itangwa kumanwa muburyo bwa capsules cyangwa igisubizo kumunwa. Irashobora kandi gutangwa mumitsi mubihe bimwe na bimwe byubuvuzi, nko mugihe cya nyuma yo kwimurwa.

Gukurikirana: Bitewe nuburinganire bwayo bwo kuvura no guhinduka kwinjizwa, tacrolimus isaba gukurikirana neza urwego rwamaraso kugirango habeho kuvura neza mugihe hagabanijwe ingaruka zuburozi. Gukurikirana imiti ivura bikubiyemo gupima buri gihe urugero rwamaraso ya tacrolimus no guhindura igipimo ukurikije izo nzego.

Ingaruka mbi: Ingaruka zisanzwe za tacrolimus zirimo nephrotoxicity, neurotoxicity, hypertension, hyperglycemia, ihungabana rya gastrointestinal, hamwe no kwandura indwara. Gukoresha igihe kirekire tacrolimus birashobora kandi kongera ibyago byo kurwara indwara zimwe na zimwe, cyane cyane kanseri y'uruhu na lymphoma.

Imikoreshereze yibiyobyabwenge: Tacrolimus ikoreshwa cyane cyane na sisitemu ya cytochrome P450, cyane cyane CYP3A4 na CYP3A5. Kubwibyo, ibiyobyabwenge bitera cyangwa bibuza iyi misemburo birashobora kugira ingaruka kuri tacrolimus mu mubiri, bikaba byaviramo kunanirwa kuvura cyangwa uburozi.

Ibitekerezo bidasanzwe: Kunywa Tacrolimus bisaba kwihererana ukurikije ibintu nkimyaka yumurwayi, uburemere bwumubiri, imikorere yimpyiko, imiti ihurira hamwe, hamwe no kwandura indwara. Gukurikiranira hafi no gukurikirana buri gihe hamwe nabashinzwe ubuvuzi nibyingenzi mugutezimbere imiti no kugabanya ingaruka mbi.