Huperzine A ｜ 120786-18-7

Huperzine A niyongerera ubwenge ubwenge ibuza imisemburo itesha agaciro imyigire ya neurotransmitter acetylcholine. Nibice bya cholinergique ya molekile ishobora gufasha kurwanya kugabanuka kwubwenge kubasaza.

Huperzine A nuruvange rwakuwe mumuryango wa huperzine. Yitwa acetylcholinesterase inhibitor, bivuze ko irinda enzyme kumena acetyloline, bigatuma kwiyongera kwa acetylcholine.

Acetylcholine yitwa neurotransmitter yiga kandi igira uruhare no kwikuramo imitsi.

Huperzine A isa nkaho ari umutekano ugereranije. Uburozi nubushakashatsi bwabantu bivuye mubushakashatsi bwinyamaswa bwerekanye ko nta ngaruka mbi zisanzwe ziyongera. Huperzine A nayo irakoreshwa mubigeragezo bibanza kugirango birinde indwara ya Alzheimer.

Huperzine A iboneka mumazi ya cerebrospinal fluid kandi byoroshye kurenga inzitizi yubwonko bwamaraso.

Huperzine A izwi cyane nka acetylcholinesterase inhibitor. By'umwihariko, irabuza G4 subtype ya acetylcholinesterase, ikunze kugaragara mu bwonko bw’inyamabere. Irakora neza cyangwa iringaniye kurwanya izindi acetylcholinesterase inhibitor, nka tacillin cyangwa rivastatine. Nka inhibitor, ifite isano ya acetylcholinesterase. Mugihe kimwe, ifite buhoro buhoro gutandukana, bigatuma igice cyacyo cyigihe kirekire.

Usibye kubuza acetylcholinesterase, irashobora no kugaragara nka neuroprotective kurwanya glutamate, beta amyloide pigmentation, hamwe n'uburozi bwa H2O2.

Huperzine A irashobora guteza imbere ikwirakwizwa rya hippocampal neural stem selile (NSCs). Bisa no guteza imbere imikurire yimitsi kuri dosiye ya biorelated.