Fludarabine | 21679-14-1

Fludarabine ni imiti ya chimiotherapie ikoreshwa cyane cyane mu kuvura ubwoko bumwe na bumwe bwa kanseri, cyane cyane indwara mbi ya hematologiya. Dore incamake:

Uburyo bwibikorwa: Fludarabine nikigereranyo cya nucleoside kibangamira synthesis ya ADN na RNA. Irabuza polymerase ya ADN, primase ya ADN, na enzymes za ADN ligase, biganisha kuri ADN kumeneka no kubuza uburyo bwo gusana ADN. Uku guhungabana kwa ADN synthesis amaherezo itera apoptose (progaramu ya progaramu ya selile) mubice bigabanya vuba, harimo na kanseri.

Ibyerekana: Fludarabine ikunze gukoreshwa mukuvura indwara ya lymphocytike idakira (CLL), kimwe nizindi ndwara mbi ziterwa na hematologiya nka lymphoma idahwitse ya Hodgkin na lymphoma selile. Irashobora kandi gukoreshwa mubihe bimwe na bimwe bya acute myeloid leukemia (AML).

Ubuyobozi: Fludarabine isanzwe ikoreshwa mu mitsi (IV) mu mavuriro, nubwo ishobora gutangwa mu kanwa mu bihe bimwe na bimwe. Ingano na gahunda byubuyobozi biterwa na kanseri yihariye ivurwa, hamwe nubuzima bwumurwayi muri rusange hamwe nuburyo yakira.

Ingaruka mbi: Ingaruka zisanzwe za fludarabine zirimo guhagarika amagufwa (biganisha kuri neutropenia, anemia, na trombocytopenia), isesemi, kuruka, impiswi, umuriro, umunaniro, no kongera kwandura indwara. Irashobora kandi gutera ingaruka mbi cyane nka neurotoxicity, hepatotoxicity, hamwe nuburozi bwibihaha mubihe bimwe na bimwe.

Icyitonderwa: Fludarabine yanduye ku barwayi bafite amagufwa akomeye cyangwa imikorere mibi yimpyiko. Igomba gukoreshwa ubwitonzi ku barwayi bafite umwijima cyangwa impyiko zahozeho, ndetse no ku bagore batwite cyangwa bonsa kubera ubushobozi bwo kwangiza uruhinja cyangwa uruhinja.

Imikoreshereze yibiyobyabwenge: Fludarabine irashobora gukorana nindi miti, cyane cyane igira ingaruka kumikorere yamagufwa cyangwa imikorere yimpyiko. Ni ngombwa ko abashinzwe ubuzima basuzuma neza imiti y’imiti y’umurwayi kandi bagakurikirana niba imiti ishobora guhura.

Gukurikirana: Gukurikirana buri gihe umubare wamaraso nimirimo yimpyiko nibyingenzi mugihe cyo kuvura hamwe na fludarabine kugirango hamenyekane ibimenyetso byerekana guhagarika amagufwa cyangwa izindi ngaruka mbi. Guhindura ibipimo birashobora gukenerwa ukurikije ibipimo byo gukurikirana.