Adenosine | 58-61-7

Adenosine, nucleoside igizwe na adenine na ribose, ifite uburyo bwinshi bwingenzi mubuvuzi na physiologiya kubera ingaruka zifatika kuri sisitemu zitandukanye mumubiri.

Ubuvuzi bw'umutima n'imitsi:

Igikoresho cyo Gusuzuma: Adenosine ikoreshwa nk'imiti igabanya ubukana bwa farumasi mugihe cyo gupimisha umutima, nka myocardial perfusion imaging. Ifasha gusuzuma indwara yimitsi yumutima itera vasodilation ya coronary, yigana ingaruka zimyitozo ngororamubiri.

Umuti wa Supraventricular Tachycardia (SVT): Adenosine numuti wambere kumurongo wo guhagarika ibice bya SVT. Cyakora mukugabanya umuvuduko unyuze kuri atrioventricular node, guhagarika inzira zisubiramo zishinzwe SVT.

Neurologiya:

Kurwanya gufata: Adenosine ni anticonvulsant ya endogenous mu bwonko. Guhindura reseptor ya adenosine birashobora kugira ingaruka za antiepileptic, kandi imiti irekura adenosine irakurikiranwa nkuburyo bushobora kuvura igicuri.

Neuroprotection: reseptor ya Adenosine igira uruhare mukurinda neurone gukomeretsa ischemic hamwe na stress ya okiside. Ubushakashatsi bugaragaza ubushobozi bwa adenosine nka agent ya neuroprotective agent mu bwonko n'indwara zifata ubwonko nka Parkinson na Alzheimer.

Ubuvuzi bw'ubuhumekero:

Bronchodilation: Adenosine ikora nka bronchodilator kandi ikoreshwa mugupima bronchoprovocation kugirango isuzume asima. Itera bronchoconstriction kubantu bafite asima, ifasha kumenya hyperreactivite yumuyaga.

Indwara ya Antarrhythmic:

Adenosine irashobora guhagarika ubwoko bumwebumwe bwa arththmias muguhindura ibikorwa byamashanyarazi mumutima, cyane cyane muri atriya no kuri atrioventricular node. Igihe gito cyubuzima bwacyo kigabanya ingaruka zifatika.

Igikoresho cy'ubushakashatsi:

Adenosine n'ibigereranyo byayo bikoreshwa cyane mubushakashatsi kugirango bige ku ruhare rw'imiti ya adenosine mu buryo butandukanye bwa physiologique na patologi. Zifasha gusobanura imikorere ya adenosine muri neurotransmission, reaction yumubiri, gutwika, no kugenzura umutima.

Uburyo bushoboka bwo kuvura:

Imiti ikomoka kuri Adenosine irakurikiranwa kugirango hashobore gukoreshwa imiti nka kanseri, gukomeretsa ischemic, gucunga ububabare, hamwe n’indwara ziterwa n’umuriro. Adenosine reseptor agonist na antagonist bari mubintu byigwaho.