Adenosine 5′-monofosifate | 61-19-8

Adenosine 5'-monophosphate (AMP) ni nucleotide igizwe na adenine, ribose, hamwe nitsinda rimwe rya fosifate.

Imiterere yimiti: AMP ikomoka kuri nucleoside adenosine, aho adenine ihurira na ribose, kandi itsinda ryiyongera rya fosifate ryometse kuri 5 'karubone ya ribose binyuze mumurongo wa fosifore.

Uruhare rwibinyabuzima: AMP nigice cyingenzi cya acide nucleique, ikora nka monomer mukubaka molekile ya RNA. Muri RNA, AMP yinjijwe mumurongo wa polymer binyuze mumigozi ya fosifori, ikora umugongo wumugozi wa RNA.

Ingufu Metabolism: AMP nayo igira uruhare mungufu zingirabuzimafatizo. Ikora nkibibanziriza diphosphate (ADP) na adenosine triphosphate (ATP) ikoresheje reaction ya fosifora iterwa na enzymes nka adenylate kinase. ATP, byumwihariko, ningufu zambere zitwara ingirabuzimafatizo, zitanga ingufu mubikorwa bitandukanye bya selile.

Amabwiriza ya Metabolic: AMP igira uruhare mukugenzura ingufu zingirabuzimafatizo. Urwego rwa AMP selile irashobora guhinduka mugusubiza impinduka za metabolike hamwe ningufu zikenewe. Urwego rwo hejuru rwa AMP ugereranije na ATP rushobora gukora inzira zingirabuzimafatizo zikoresha ingufu za selile, nka protein kinase ikora AMP (AMPK), igenga metabolism kugirango ibungabunge ingufu homeostasis.

Inkomoko y'ibiryo: AMP irashobora kuboneka mu masoko y'ibiryo, cyane cyane mu biribwa bikungahaye kuri acide nucleique, nk'inyama, amafi, n'ibinyamisogwe.

Porogaramu ya Farumasi: AMP n'ibiyikomokaho byakorewe iperereza kubishobora kuvurwa. Kurugero, cAMP (cyclic AMP), ikomoka kuri AMP, ikora nkintumwa ya kabiri munzira zo guhererekanya ibimenyetso kandi yibasiwe nibiyobyabwenge bitandukanye kugirango bivure indwara nka asima, indwara z'umutima n'imitsi, hamwe nubusumbane bwa hormone.